Modulation of Brain-Derived Neurotrophic Factor (BDNF)-Induced Trophic Signalling as an Alternative Treatment for Alzheimer’s Disease
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چکیده
Alzheimer’s disease (AD) is a disorder of synaptic function and neuronal degeneration characterized by decline in memory and cognition as well as changes of personality. Brain-Derived Neurotrophic Factor (BDNF) is a major modulator of synaptic plasticity and is an acknowledged pharmacological target for the treatment of a range of neurological disorders including AD. Attempts to supply BDNF exogenously are limited by side eff ects. An alternative strategy to enhance BDNF-induced trophic signalling is through amplifi cation of neural response to the reduced supply of endogenous BDNF found in AD.
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